Millen, the county seat for Jenkins County and only minutes from the Ogeechee River, has been a regional hub of transportation in Georgia since 1854 when the railroad came to town. Cotton Avenue is an excellent example of a railroad commercial district. The Central Railroad Company built a line between Savannah and Macon via Millen in the 1830s; a north-south line from Millen to Augusta built by the Savannah Railroad in 1852 turned Millen into a major trade post. 

Two major depots located along Cotton Avenue indicate the significance of rail transportation in Millen. Both built in the early 1900s, one is currently in use by Norfolk Southern and the other houses the Millen-Jenkins County Museum and Chamber of Commerce. As many as fifteen trains passing through Millen daily.

Millen is also home to one of Georgia's most beautiful state parks, Magnolia Springs State Park, which is known for its crystal clear springs that flow at an estimated nine million gallons of water per day.